After 1925, Freundlich lived and worked mainly in France. In Germany, his work was condemned by the Nazis as degenerate and removed form public display. Some works were seized and displayed at the infamous Nazi exhibition of degenerate art including his monumental sculpture Der Neue Mensch (The New Man) which was photographed unsympathetically and used as the cover illustration of the exhibition catalogue. Der Neue Mensch was never recovered and is assumed to have been destroyed.
With outbreak of World War II, Freundlich was interned by the French authorities but released, for a time, under the influence of Pablo Picasso. In 1943 he was arrested and deported to Majdanek Concentration Camp, where he was murdered on the day he arrived.