An Old Man and his Grandson Circa 1490 by Domenico Ghirlandaio. Tempera on panel, 62.7 cm x 46.3 cm. Louvre, Paris.

File:Domenico ghirlandaio, ritratto di nonno con nipote.jpg

The deformity of the man's nose is evidence of rhinophyma, a large, bulbous, ruddy nose caused by granulomatous infiltration, commonly due to untreated rosacea.

File:Pala degli innocenti, ghirlandaio, autoritratto.jpg

Supposed self-portrait, from Adoration of the Magi, 1488